Cardiovascular Disease
Several studies have demonstrated that, in a range of populations, postprandial hyperglycaemia or IGT is associated with an increased risk of cardiovascular mortality. The elevated risk of CVD associated with IGT is, in part, owing to the vascular damage induced and exacerbated by hyperglycaemia. Postprandial hyperglycaemia damages the vasculature through a number of mechanisms, many of which are driven by hyperglycaemia-induced oxidative stress. Vascular damage accelerates atherosclerosis and increases the risk of cardiovascular events.
Postprandial hyperglycaemia or IGT is associated with an increased risk of cardiovascular mortality.
Individuals with prediabetes are 34% more likely to die from CVD than healthy individuals.
The elevated cardiovascular risk associated with IGT is independent of the development of type 2 diabetes.
Two-thirds of patients admitted to hospital with CAD have dysglycaemia (diabetes or prediabetes).
The risk of cardiovascular mortality increases continuously with 2hPG levels, and is elevated even at levels below that used to identify prediabetes.
Blood glucose level at hospital admission for myocardial infarction (MI) is an independent predictor of longterm patient prognosis.
